Scleroderma - an auto immune disease that affects the skin

Scleroderma is an auto immune disease that affects the skin. This affect connective tissues leading to inflation, scars and thickening of skin. Most commonly skin over tips of elbows, fingers and face. Mostly women are more affected by the disease than men. Scleroderma can be classified into two diffuse and limited. In diffuse form skin of face, chest, abdomen etc thickens symmetrically. Some times organ diseases also occur which might be serious. Bowels, lungs, heart, esophagus and kidneys are most commonly affected. It can even lead to high blood pressure. In limited form only skin of face and fingers are effected. This effect takes place slowly and is also known as CREST. As per this name CREST

C stands for tiny calcium deposits called calcinosis, commonly found in elbows, knees etc in white colour in superficial skin. This might need a surgery or might be tender enough to fall off if infected.

R is for Raynaud's phenomenon which is spasm of small artery vessels. Commonly they are found in arteries to fingers, nose, tounge, ears or toes. They change colour to blue, white and then red when exposed to extreme heat, cold or emotions.

E goes for Esophagus, the condition in which muscles function poorly or lower part of esophagus stops functioning. Esophagus may widen leading to backflow of stomach acid causing heartburn, scarring or inflammation.

S refers to Sclerodactyly ie. tightening or thickening of skin of toes and fingers. This may limit the motion of fingers and toes and they will appear puffy and shiny.

Finally T is for Telangiectasias, tiny red spots that blanch on pressing and represents dilated capillaries on face, mouth or hands. It is not necessary that all these symptoms exist along.

When the disease diffuse it is called as systemic sclerosis. Some might also be affected with some other connective tissue diseases. When symptoms of scleroderma are found with systemic lupus erythematosus symptoms or of polymyositis it is called mixed connective tissue disease (MCTD). Linear scleroderma is a condition in which hardened skin is found as a strip along leg. If affected to a child this can stunt bone growth of affected leg. The disease can be dangerous to your heart leading to conditions like myocardial disease, arrhythmias or conduction system abnormalities. Kidneys and lungs are also affected due to tightening of blood vessels.


Skin hardening
Progressive tissue fibrosis
Occlusion of the microvasculature
Calcium gets deposited in connective tissues
Blood vessels of hands and feet narrows
Swellimg of esophagus
Red spots on face and hands
Sensitivity to cold


It is found that genes has a role in causing Scleroderma. Cellular and humoral immunological derangement is considered as a cause of this disease. Activation of fibroblast and injury to Endothelial cell are other causes. At times environment also plays a vital role. Exposure to silica, to solvents like trichloroethylene, benzene, vinyl chloride, epoxy resins, carbon tetrachloride, radiation or radio therapy are environmental factors leading to this disease. When environmental or genetic factors activate the immune system causing injury to tissues patient is affected by this disease. parvovirus B19 is an accelerating agent like human herpesvirus 5 and Cytomegalovirus. Families with Scleroderma patients are found to be affected with other autoimmune diseases also. Body tissues are affected by its own immune system leading to this disease. Certain drugs like Bleomycin and pentazocine can also cause this disease.


As this particular disease can lead to several other problems it is better to consult a rheumatologist. He will refer you to other specialists like a dermatologist, a nephrologist, a cardiologist, a gastroenterologist, a pulmonary specialist etc for different problems faced by you. Medicines like Pantoprazole (Protonix), is used to treat ulcer in stomach. For that affecting heat medicines like nifedipine, bosentan, nicardipine are prescriped as they are calcium channel blockers. Skin discolouration and hardening is treated with corticosteroids or moisturizers. In extensive form antibiotics like minocycline is prescribed. Phototherapy also gives some positive results. Vasodilators are used for relaxation and there by help to expansion of blood vessels. Angiotensin converting enzyme (ACE) inhibitors can be given to maintain blod pressure. Aspirin, naproxen, ibuprofen etc can be given as Nonsteroidal anti-inflammatory drugs. Antacids help digestion and decrease acidity while D-penicillamine delays the spreading of disease. Steroids are prescribed to reduce inflammation. Cyclophosphamide and methotrexate are immunosuppressants. At times cosmetic or orthopedic surgery is necessary to correct contractures of joints, to treat scars or skin deformities. Stretching exercise helps to keep joints flexible and strong. Avoiding Vitamin C greater than 100mg/day and excessive smoking are other methods necessary.

Alternative medicine

It is found that herbs can cure scleroderma to a good extent. Extracts from hydrangea root, a herb commonly used in Chinese medicine was proved effective in halting the progress of an autoimmune disease in lab and is yet to be proved on a human body. Acupuncture can relieve from the symptoms of sclerosis. Among Chinese medications are treatments using medical extracts from dried beetles, earth worms, scorpions, centipedes etc. One of the chinese medicines are Yangshen Huoxue Tang a combination of extracts to warm kidney and vitalize blood. Different herbs used in Chinese medicine are effective blood vitalers, yang tonics, spleen qi tonics and warming agents. Rehmania is a common herb used in medicines. Cornus is another herb used to treat kidney. Meditation and yoga are found effective to reduce tension, depression and anxiety caused by scleroderma. Transcendental Meditation is helpful to reduce brain's response to pain. It is said that you can control the disease by changing life style, by introducing healthy diet, regular physical exercise and body cleansing along with different natural traditional therapies.


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