Gangrene - Peripheral Vascular Disease
Gangrene is the death of tissue in part of the body.
Gangrene can occur when a body part loses its blood supply. This may happen from, for example, injury or infection. You have a higher risk for gangrene if you have:
Blood vessel disease (such as arteriosclerosis in your arms or legs)
Diabetes
A serious injury
Surgery
Immunosuppression (for example, from HIV or chemotherapy)
Gangrene refers to the decay and death of tissue resulting from an interruption in blood flow to a certain area of your body. Some types of gangrene also involve a bacterial infection. Gangrene most commonly affects the extremities, including your toes, fingers and limbs, but can also occur in your muscles and internal organs.
Treatment is usually surgical debridement and excision with amputation is necessary in many cases. Antibiotics alone are not effective because they do not penetrate ischemic muscles sufficiently. However, penicillin is given as an adjuvant treatment to surgery. In addition to surgery and antibiotics, Hyperbaric oxygen therapy (HBOT) is used to inhibit the growth of and kill the anaerobic C. perfringens.
Refer the following links for more details
http://en.wikipedia.org/wiki/Gangrene
http://mplus.nlm.nih.gov/medlineplus/ency/article/007218.htm
http://www.mayoclinic.com/health/gangrene/DS00993
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